論文 - 詳細
| RRC ID | 87002 |
|---|---|
| 著者 | Prizant H, Patil N, Negatu S, Bala N, McGurk A, Leddon SA, Hughson A, McRae TD, Gao YR, Livingstone AM, Groom JR, Luster AD, Fowell DJ. |
| タイトル | CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter. |
| ジャーナル | Cell Rep |
| Abstract |
Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation. We reveal that tissue entry and initial peripheral activation of Th1 effector T cells are tightly linked to perivascular positioning of chemokine-expressing APCs. Dermal inflammation induces tissue-wide de novo generation of discrete perivascular CXCL10+ cell clusters, enriched for CD11c+MHC-II+ monocyte-derived dendritic cells. These chemokine clusters are "hotspots" for both Th1 extravasation and activation in the inflamed skin. CXCR3-dependent Th1 localization to the cluster micro-environment prolongs T-APC interactions and boosts function. Both the frequency and range of these clusters are enhanced via a T helper 1 (Th1)-intrinsic, interferon-gamma (IFNγ)-dependent positive-feedback loop. Thus, the perivascular CXCL10+ clusters act as initial peripheral activation niches, optimizing controlled activation broadly throughout the tissue by coupling Th1 tissue entry with enhanced opportunities for Th1-APC encounter. |
| 巻・号 | 36(6) |
| ページ | 109523 |
| 公開日 | 2021-8-10 |
| DOI | 10.1016/j.celrep.2021.109523 |
| PII | S2211-1247(21)00954-2 |
| PMID | 34380032 |
| PMC | PMC9218982 |
| MeSH | Animals Antigen-Presenting Cells / metabolism* Antigens / metabolism Antigens, CD / metabolism Cell Aggregation Chemokine CXCL10 / metabolism* Ear / pathology Histocompatibility Antigens Class II / metabolism Humans Inflammation / pathology Interferon-gamma Lymphocyte Activation / immunology* Mice Mice, Transgenic Receptors, CXCR3 / metabolism Skin / pathology Th1 Cells / immunology* |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05737 |