| RRC ID |
87160
|
| Author |
Chen H, Yang G, Xu DE, Du YT, Zhu C, Hu H, Luo L, Feng L, Huang W, Sun YY, Ma QH.
|
| Title |
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner.
|
| Journal |
Neurosci Bull
|
| Abstract |
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.
|
| Volume |
41(3)
|
| Pages |
374-390
|
| Published |
2025-3-1
|
| DOI |
10.1007/s12264-024-01292-1
|
| PII |
10.1007/s12264-024-01292-1
|
| PMID |
39283565
|
| PMC |
PMC11876512
|
| MeSH |
Aging* / pathology
Aging* / physiology
Animals
Autophagy* / physiology
Brain / cytology
Brain / growth & development
Cell Count
Cell Lineage / physiology
Cells, Cultured
Mice
Mice, Inbred C57BL
Myelin Basic Protein / metabolism
Myelin Sheath* / metabolism
Myelin Sheath* / physiology
Oligodendrocyte Precursor Cells
Oligodendroglia* / metabolism
Oligodendroglia* / physiology
|
| IF |
4.326
|
| Resource |
| Mice |
RBRC02759 |
