論文 - 詳細
| RRC ID | 87197 |
|---|---|
| 著者 | Buchtler S, Frühauf A, Neumayer S, Schmidbauer K, Talke Y, Winter-Köhler F, Balam S, Landgraf K, Gebhard C, Rehli M, Schlieckau FV, Beck M, Günther F, Fleck M, Renner K, Mack M. |
| タイトル | Fibrosis-memory is mediated by IL-3-producing T cells and drives progression of fibrosis. |
| ジャーナル | J Clin Invest |
| Abstract |
Repetitive injuries are an important trigger of progressive fibrosis. To study if repetitive injuries induce an accelerated profibrotic process, also called "fibrosis-memory," we established an experimental system with two consecutive, clearly separated insults in a model of renal fibrosis with reversible and irreversible unilateral ureteral obstruction. We found that a preceding fibrotic event of one kidney markedly enhanced subsequent development of fibrosis in the contralateral kidney. Aggravation of fibrosis during the second insult was dependent on memory CD4+ T cells. T cell depletion abrogated the fibrosis-memory effect, while adoptive transfer of memory T cells from fibrotic mice enhanced fibrosis in the recipients. Moreover, IL-3 production by memory CD4+ T cells was essential for aggravation of fibrosis in memory situations. In patients with systemic sclerosis, IL-3 expression by T cells was markedly increased, especially after a long disease duration accompanied by involvement of internal organs. In summary, our data identify IL-3-mediated fibrosis-memory as an important driver of progressive fibrosis. |
| 巻・号 | 136(6) |
| 公開日 | 2026-3-16 |
| DOI | 10.1172/JCI192095 |
| PII | 192095 |
| PMID | 41837289 |
| PMC | PMC12987615 |
| MeSH | Adoptive Transfer Animals CD4-Positive T-Lymphocytes* / immunology CD4-Positive T-Lymphocytes* / metabolism CD4-Positive T-Lymphocytes* / pathology Disease Progression Female Fibrosis Humans Immunologic Memory* Interleukin-3* / biosynthesis Interleukin-3* / genetics Interleukin-3* / immunology Kidney* / immunology Kidney* / pathology Kidney Diseases* / immunology Kidney Diseases* / pathology Male Memory T Cells* / immunology Memory T Cells* / pathology Mice Mice, Inbred C57BL Scleroderma, Systemic / immunology Scleroderma, Systemic / pathology Ureteral Obstruction / immunology Ureteral Obstruction / pathology |
| IF | 11.864 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.7 |
| リソース情報 | |
| 実験動物マウス | RBRC02298 |