論文 - 詳細
| RRC ID | 87199 |
|---|---|
| 著者 | Zhou H, Moriyasu D, Hsiao SW, Yamaguchi Y, Azuma M, Koshimizu TA, Itoi K, Sakimura K, Schwartz WJ, Okamura H, Hasegawa E, Doi M. |
| タイトル | Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus. |
| ジャーナル | Commun Biol |
| Abstract |
Understanding the network topology of a cluster of diverse neurons acting in concert requires a detailed expression map of ligand-receptor pairs involved in cell-cell communication. The neuropeptide arginine vasopressin (AVP) and signaling mediated by its cognate receptor V1a have been implicated in dorsal-to-ventral regional communication in the suprachiasmatic nucleus (SCN), a cluster of neurons that acts in concert to generate daily rhythms in behavior and physiology. Here, we show that among vasoactive intestinal peptide (VIP)-ergic neurons in the ventral SCN only a small subpopulation expresses V1a, and we demonstrate the requirement of V1a in these VIP neurons for maintaining the robustness of the circadian clock using a jet-lag paradigm. Notably, we found that V1a expression appears to be minimal in the other major ventral neuronal population expressing gastrin-releasing peptide (GRP). The identified heterogeneity between VIP and GRP neurons, and among VIP neurons, provides a basic map for understanding the cryptic network structure from dorsal AVP neurons to receiver ventral SCN. |
| 巻・号 | 9(1) |
| 公開日 | 2026-2-12 |
| DOI | 10.1038/s42003-026-09694-9 |
| PII | 10.1038/s42003-026-09694-9 |
| PMID | 41680426 |
| PMC | PMC13009381 |
| MeSH | Animals Arginine Vasopressin / metabolism Circadian Rhythm Gastrin-Releasing Peptide* / genetics Gastrin-Releasing Peptide* / metabolism Male Mice Mice, Inbred C57BL Neurons* / metabolism Receptors, Vasopressin* / genetics Receptors, Vasopressin* / metabolism Signal Transduction* Suprachiasmatic Nucleus* / cytology Suprachiasmatic Nucleus* / metabolism Suprachiasmatic Nucleus* / physiology Vasoactive Intestinal Peptide* / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 実験動物マウス | RBRC10694 |