論文 - 詳細
| RRC ID | 87208 |
|---|---|
| 著者 | Yoshihara T, Okabe Y. |
| タイトル | Aldh1a2 + fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots. |
| ジャーナル | J Exp Med |
| Abstract |
Lymphoid clusters in visceral adipose tissue omentum, known as milky spots, play a central role in the immunological defense in the abdomen. Milky spots exhibit hybrid nature between secondary lymph organs and ectopic lymphoid tissues, yet their development and maturation mechanisms are poorly understood. Here, we identified a subset of fibroblastic reticular cells (FRCs) that are uniquely present in omental milky spots. These FRCs were characterized by the expression of retinoic acid-converting enzyme, Aldh1a2, and endothelial cell marker, Tie2, in addition to canonical FRC-associated genes. Diphtheria toxin-mediated ablation of Aldh1a2+ FRCs resulted in the alteration in milky spot structure with a significant reduction in size and cellularity. Mechanistically, Aldh1a2+ FRCs regulated the display of chemokine CXCL12 on high endothelial venules (HEVs), which recruit blood-borne lymphocytes from circulation. We further found that Aldh1a2+ FRCs are required for the maintenance of peritoneal lymphocyte composition. These results illustrate the homeostatic roles of FRCs in the formation of non-classical lymphoid tissues. |
| 巻・号 | 220(5) |
| 公開日 | 2023-5-1 |
| DOI | 10.1084/jem.20221813 |
| PII | 213908 |
| PMID | 36880532 |
| PMC | PMC9997506 |
| MeSH | Fibroblasts Germinal Center Lymphocytes* Lymphoid Tissue Omentum* Peritoneum Retinal Dehydrogenase / metabolism |
| IF | 11.743 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 35 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00267 |