Reference - Detail
| RRC ID | 87213 |
|---|---|
| Author | Ito Y, Nakahara F, Kagoya Y, Kurokawa M. |
| Title | CD62L expression level determines the cell fate of myeloid progenitors. |
| Journal | Stem Cell Reports |
| Abstract |
Hematopoietic cells differentiate through several progenitors in a hierarchical manner, and recent single-cell analyses have revealed substantial heterogeneity within each progenitor. Although common myeloid progenitors (CMPs) are defined as a multipotent cell population that can differentiate into granulocyte-monocyte progenitors (GMPs) and megakaryocyte-erythrocyte progenitors (MEPs), and GMPs generate neutrophils and monocytes, these myeloid progenitors must contain some lineage-committed progenitors. Through gene expression analysis at single-cell levels, we identified CD62L as a marker to reveal the heterogeneity. We confirmed that CD62L-negative CMPs represent "bona fide" CMPs, whereas CD62L-high CMPs are mostly restricted to GMP potentials both in mice and humans. In addition, we identified CD62L-negative GMPs as the most immature subsets in GMPs and Ly6C+CD62L-intermediate and Ly6C+CD62L-high GMPs are skewed to neutrophil and monocyte differentiation in mice, respectively. Our findings contribute to more profound understanding about the mechanism of myeloid differentiation. |
| Volume | 16(12) |
| Pages | 2871-2886 |
| Published | 2021-12-14 |
| DOI | 10.1016/j.stemcr.2021.10.012 |
| PII | S2213-6711(21)00547-6 |
| PMID | 34798065 |
| PMC | PMC8693656 |
| MeSH | Animals Cell Differentiation Cell Lineage* Gene Expression Profiling Gene Expression Regulation Humans L-Selectin / metabolism* Megakaryocytes / cytology Megakaryocytes / metabolism Mice Mice, Inbred C57BL Monocytes / cytology Monocytes / metabolism Myeloid Progenitor Cells / cytology* Myeloid Progenitor Cells / metabolism* Neutrophils / cytology Neutrophils / metabolism |
| IF | 6.032 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00267 |