論文 - 詳細
| RRC ID | 87351 |
|---|---|
| 著者 | Vuong LT, Mlodzik M. |
| タイトル | Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule-associated complex requires Pasovec/Gid8 proteins. |
| ジャーナル | Sci Adv |
| Abstract |
Wg/Wnt signaling is critical throughout development and homeostasis and associated with many diseases, including cancer. Wg/Wnt signaling is mediated by β-catenin (Armadillo/Arm in Drosophila) with the IFT-A/Kinesin2 complex promoting nuclear translocation of β-catenin/Arm. Existing information suggests that additional proteins are involved. Here, we demonstrate that a conserved protein, Pasovec (Psv; Gid8 in mammals), with loss-of-function mutants resembling wg and arm/β-catenin mutant phenotypes, is required for nuclear β-catenin/Arm localization. Psv interacts with the IFT-A/Kinesin2 complex, physically binding IFT140, a core component of IFT-A. The Psv/Gid8-IFT140 association is independent of Wg/Wnt-signaling activation. Psv/Gid8 contains a CRA domain, identified as interacting with RanBPM, which mediates its nuclear localization. Mutations in CRA affect Psv/Gid8's own nuclear localization and that of β-catenin/Arm upon Wg/Wnt-signaling activation. Psv with a mutated CRA can act as an inhibitor of Wg/Wnt signaling. Together, this study describes a previously unidentified factor, required for Wg/Wnt signaling, that functions during the nuclear translocation process of β-catenin/Arm. |
| 巻・号 | 12(14) |
| ページ | eaea3382 |
| 公開日 | 2026-4-3 |
| DOI | 10.1126/sciadv.aea3382 |
| PMID | 41931626 |
| PMC | PMC13048246 |
| MeSH | Active Transport, Cell Nucleus Animals Armadillo Domain Proteins / metabolism Cell Nucleus* / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Humans Microtubule-Associated Proteins* / genetics Microtubule-Associated Proteins* / metabolism Microtubules* / metabolism Mutation Protein Binding Wnt Signaling Pathway* Wnt1 Protein* / genetics Wnt1 Protein* / metabolism beta Catenin* / genetics beta Catenin* / metabolism |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.5 |
| リソース情報 | |
| ショウジョウバエ | 18467R-2 |