Reference - Detail
| RRC ID | 87390 |
|---|---|
| Author | Hu D, Masai I. |
| Title | Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition. |
| Journal | Nat Commun |
| Abstract |
Cone photoreceptors assemble to form a regular mosaic pattern in vertebrate retinas. In zebrafish, four distinct spectral cone types (red, green, blue, and ultraviolet), form a lattice-like pattern. However, the mechanism of cone mosaic formation has been unknown. Here we show that Down Syndrome Cell Adhesion Molecule b (Dscamb) regulates the cone mosaic pattern in zebrafish, especially via red-cone spacing. During photoreceptor differentiation, newly formed cones extend filopodium-like processes laterally to apical surfaces of neighboring cones. Interestingly, red cones extend filopodia, but promptly retract them when they meet their own cone type, suggesting filopodium-mediated, homotypic recognition and self-avoidance. This self-avoidance is compromised in zebrafish dscamb mutants, leading to abnormal clustering of red cones and subsequent disruption of regular cone spacing. Thus, apical filopodium-mediated spacing of the same cone type depends on Dscamb and is essential for cone mosaic formation in zebrafish. |
| Volume | 16(1) |
| Pages | 2501 |
| Published | 2025-3-25 |
| DOI | 10.1038/s41467-025-57506-1 |
| PII | 10.1038/s41467-025-57506-1 |
| PMID | 40133281 |
| PMC | PMC11937385 |
| MeSH | Animals Cell Adhesion Molecules* / genetics Cell Adhesion Molecules* / metabolism Cell Differentiation Mutation Pseudopodia* / metabolism Retinal Cone Photoreceptor Cells* / cytology Retinal Cone Photoreceptor Cells* / metabolism Retinal Cone Photoreceptor Cells* / physiology Zebrafish* / genetics Zebrafish* / metabolism Zebrafish Proteins* / genetics Zebrafish Proteins* / metabolism |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | UAS:GFP |