Reference - Detail
| RRC ID | 87436 |
|---|---|
| Author | Álvarez C, Ángeles Bermúdez M, Romero LC, Gotor C, García I. |
| Title | Cysteine homeostasis plays an essential role in plant immunity. |
| Journal | New Phytol |
| Abstract |
• Cysteine is the metabolic precursor of essential biomolecules such as vitamins, cofactors, antioxidants and many defense compounds. The last step of cysteine metabolism is catalysed by O-acetylserine(thiol)lyase (OASTL), which incorporates reduced sulfur into O-acetylserine to produce cysteine. In Arabidopsis thaliana, the main OASTL isoform OAS-A1 and the cytosolic desulfhydrase DES1, which degrades cysteine, contribute to the cytosolic cysteine homeostasis. • Meta-analysis of the transcriptomes of knockout plants for OAS-A1 and for DES1 show a high correlation with the biotic stress series in both cases. • The study of the response of knockout mutants to plant pathogens shows that des1 mutants behave as constitutive systemic acquired resistance mutants, with high resistance to biotrophic and necrotrophic pathogens, salicylic acid accumulation and WRKY54 and PR1 induction, while oas-a1 knockout mutants are more sensitive to biotrophic and necrotrophic pathogens. However, oas-a1 knockout mutants lack the hypersensitive response associated with the effector-triggered immunity elicited by Pseudomonas syringae pv. tomato DC3000 avrRpm1. • Our results highlight the role of cysteine as a crucial metabolite in the plant immune response. |
| Volume | 193(1) |
| Pages | 165-177 |
| Published | 2012-1-1 |
| DOI | 10.1111/j.1469-8137.2011.03889.x |
| PMID | 21988475 |
| MeSH | Arabidopsis / enzymology Arabidopsis / genetics Arabidopsis / immunology* Arabidopsis / microbiology Carbon-Oxygen Lyases / genetics Carbon-Oxygen Lyases / metabolism Cysteine / metabolism* Cytosol / metabolism Disease Resistance / genetics Disease Resistance / immunology Gene Expression Regulation, Plant Glutathione / metabolism Homeostasis / immunology* Host-Pathogen Interactions / genetics Host-Pathogen Interactions / immunology Mutation / genetics Oxidation-Reduction Plant Immunity* / genetics Pseudomonas syringae / physiology RNA, Messenger / genetics RNA, Messenger / metabolism Salicylic Acid / metabolism Stress, Physiological / genetics Sulfhydryl Compounds / metabolism Time Factors Transcription, Genetic Transcriptome / genetics |
| IF | 8.512 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Arabidopsis / Cultured plant cells, genes | pst16025 |