| RRC ID |
87488
|
| Author |
Ostenrath AM, Faturos N, Çiftci Çobanoğlu YI, Serneels B, Jeong I, Dongel Dayanc E, Enz A, Hinrichsen F, Mutlu AK, Bardenhewer R, Jetti SK, Neuhauss SCF, Jurisch-Yaksi N, Yaksi E.
|
| Title |
Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.
|
| Journal |
Nat Commun
|
| Abstract |
Inhibition plays a key role in brain functions. While typically linked to GABA, inhibition can be induced by glutamate via metabotropic glutamate receptors (mGluRs). Here, we investigated the role of mGluR-mediated inhibition in the habenula, a conserved, glutamatergic brain hub involved in adaptive and defensive behaviors. We found that zebrafish and mice habenula express group III mGluRs. We showed that group III mGluRs regulate membrane potential and calcium activity of zebrafish habenula. Perturbing group III mGluRs increased sensory-evoked excitation and reduced selectivity. We identified inhibition as the primary communication mode among habenula neurons. Blocking group III mGluRs reduces this inhibition and increases neural synchrony. Consistently, we demonstrated that multisensory integration in the habenula relies on competitive suppression, that partly depends on group III mGluRs. Genetic and pharmacological perturbation of group III mGluRs amplified neural responses and defensive behaviors. Our findings highlight an essential role for mGluR-driven inhibition in encoding information and regulating defensive behaviors.
|
| Volume |
16(1)
|
| Pages |
7187
|
| Published |
2025-8-5
|
| DOI |
10.1038/s41467-025-62115-z
|
| PII |
10.1038/s41467-025-62115-z
|
| PMID |
40764295
|
| PMC |
PMC12325729
|
| MeSH |
Animals
Behavior, Animal* / physiology
Calcium / metabolism
Female
Habenula* / metabolism
Habenula* / physiology
Male
Membrane Potentials / physiology
Mice
Mice, Inbred C57BL
Neural Inhibition* / physiology
Neurons / metabolism
Neurons / physiology
Receptors, Metabotropic Glutamate* / antagonists & inhibitors
Receptors, Metabotropic Glutamate* / genetics
Receptors, Metabotropic Glutamate* / metabolism
Zebrafish
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism
|
| IF |
12.121
|
| Resource |
| Zebrafish |
Tg(dao:GAL4VP16)rw0148a
Tg(narp:GAL4VP16)rw0143a |
