論文 - 詳細
| RRC ID | 87510 |
|---|---|
| 著者 | Kishida K, Kawakami K, Tanabe H, Nakai W, Yonekura K, Yokoyama S, Arase H. |
| タイトル | Immune-induced TCR-like antibodies regulate specific T cell response in mice. |
| ジャーナル | Nat Commun |
| Abstract |
Antigen-specific regulation of T cell response is crucial for limiting hyperimmune response. However, the molecular mechanisms governing specific immune regulation remain unclear. In this study, we discover that antibodies specific to the antigen peptide-MHC class II complex are produced during helper T cell responses to various antigens, including hen egg lysozyme and proteolipid protein peptide. These antibodies specifically inhibit T cell receptor (TCR) recognition of MHC class II molecules presenting specific antigen peptide. We term these antibodies 'immune-induced TCR-like antibodies' or iTabs. Immunization with peptides containing flanking residues induces iTabs whereas immunization with peptides lacking flanking residues does not. Furthermore, we show that immunization with iTab-inducible peptide or iTab treatment suppress autoimmune disease development in a mouse model of experimental autoimmune encephalomyelitis. Thus, our findings provide a strategy for suppressing antigen-specific helper T cell responses using specific peptides, potentially controlling autoimmune diseases. |
| 巻・号 | 17(1) |
| 公開日 | 2026-4-16 |
| DOI | 10.1038/s41467-026-71384-1 |
| PII | 10.1038/s41467-026-71384-1 |
| PMID | 41991935 |
| PMC | PMC13087043 |
| MeSH | Animals Antibodies* / immunology Encephalomyelitis, Autoimmune, Experimental* / immunology Female Histocompatibility Antigens Class II / immunology Immunization Mice Mice, Inbred C57BL Muramidase / immunology Peptides / immunology Receptors, Antigen, T-Cell* / immunology T-Lymphocytes, Helper-Inducer* / immunology |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 39.5 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |