論文 - 詳細
| RRC ID | 87568 |
|---|---|
| 著者 | Garibağaoğlu R, Kobayashi R, Hanashiro V, Tomita J, Kume K. |
| タイトル | The effect of L-alanine on sleep through taste properties in Drosophila melanogaster. |
| ジャーナル | Neurosci Res |
| Abstract |
Sleep and nutrition are important for the survival of organisms. This study focuses on the effects of amino acids, specifically L-alanine, on sleep of Drosophila melanogaster. Some amino acids including L-alanine are shown to be attractive to flies. To assess their effect on sleep, either sucrose (sweet) or sorbitol (non-sweet) was used as a base sugar of the food. Sleep was measured using monitors with infrared beams, and feeding behavior was examined by food intake and proboscis extension response tests. L-alanine supplementation in a sweet diet did not alter sleep, but supplementation in a non-sweet diet increased sleep. The addition of non-nutritive sweetener, sucralose to a non-sweet diet also increased sleep, but combining sucralose with L-alanine did not produce additive effects. L-alanine also increased the lifespan of aged flies when supplemented in a non-sweet diet. These findings suggest that the attractive taste properties of L-alanine induced sleep and offer new insights into the relationship between sleep and taste. |
| 巻・号 | 218 |
| ページ | 104924 |
| 公開日 | 2025-9-1 |
| DOI | 10.1016/j.neures.2025.104924 |
| PII | S0168-0102(25)00107-5 |
| PMID | 40517958 |
| MeSH | Alanine* / pharmacology Animals Drosophila melanogaster / physiology Feeding Behavior / drug effects Female Longevity / drug effects Male Sleep* / drug effects Sleep* / physiology Sorbitol / pharmacology Sucrose / analogs & derivatives Sucrose / pharmacology Taste* / drug effects Taste* / physiology |
| IF | 2.645 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#150534 |