論文 - 詳細
| RRC ID | 87584 |
|---|---|
| 著者 | Gomez JM, Bevilacqua C, Thayambath A, Heriche JK, Leptin M, Belmonte JM, Prevedel R. |
| タイトル | Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation. |
| ジャーナル | Nat Commun |
| Abstract |
During development, three-dimensional morphology arises from the balance of forces acting on cells and tissues, and their material properties. Cellular forces have been investigated, however the characterisation and specification of cell material properties remains poorly understood. Here, we characterise and spatially map in three dimensions the dynamics of the longitudinal modulus at GHz frequencies to characterise the evolving blastoderm material properties during Drosophila gastrulation utilising line-scan Brillouin microscopy. We find that blastoderm cells undergo rapid and spatially varying changes in their material properties and that these differ in cells with different fates and behaviours. We identify microtubules as potential mechano-effectors, and develop a physical model to understand the role of localised and dynamic changes in material properties during tissue folding. Our work provides the first spatio-temporal description of evolving material properties during organismal morphogenesis, and highlights the potential of Brillouin microscopy for studying the dynamic changes in cell shape and cell material properties simultaneously. |
| 巻・号 | 16(1) |
| ページ | 6473 |
| 公開日 | 2025-7-14 |
| DOI | 10.1038/s41467-025-61702-4 |
| PII | 10.1038/s41467-025-61702-4 |
| PMID | 40659644 |
| PMC | PMC12259986 |
| MeSH | Animals Biomechanical Phenomena Blastoderm / cytology Cell Shape Drosophila* / embryology Drosophila melanogaster* / embryology Embryo, Nonmammalian / cytology Gastrulation* / physiology Microtubules / metabolism Morphogenesis |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 57 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115301 |