Reference - Detail
| RRC ID | 87585 |
|---|---|
| Author | Cao TTT, Nguyen TA, Nguyen MHC, Ngo Trang TTH, Dang TTP. |
| Title | Critical roles of Drosophila ubiquitin carboxyl-terminal hydrolase in eye development. |
| Journal | Life Sci Alliance |
| Abstract |
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a protein in the ubiquitin-proteasome system involved in numerous cellular processes and implicated in various human diseases, including cancer, neurodegenerative diseases, and metabolic syndrome. However, its roles in development remain poorly understood. In this study, we used Drosophila melanogaster as a model to investigate the function of UCH-L1. The Drosophila homolog of UCH-L1, Uch, was specifically knocked down in the eye imaginal disk using RNA interference (RNAi). The results showed that loss of Uch function induced a rough eye phenotype characterized by abnormal ommatidia, including disorganized arrangement, variable sizes, and irregular orientations. In addition, Uch knockdown significantly affected cone cells, photoreceptor cells, and pigment cells. Remarkably, these defects were fully rescued when rho-1, a protease that releases the Spitz, the ligand of EGFR signaling, was co-knocked down. Taken together, these findings strongly demonstrated that Uch plays a crucial role in the development of various Drosophila eye cell types and functions in coordination with rhomboid-1 in the Drosophila EGFR signaling pathway. |
| Volume | 8(11) |
| Published | 2025-11-1 |
| DOI | 10.26508/lsa.202503246 |
| PII | 8/11/e202503246 |
| PMID | 40825585 |
| PMC | PMC12360465 |
| MeSH | Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Drosophila melanogaster* / metabolism ErbB Receptors / metabolism Eye* / embryology Eye* / growth & development Eye* / metabolism Imaginal Discs / metabolism Phenotype RNA Interference Signal Transduction Ubiquitin Thiolesterase* / genetics Ubiquitin Thiolesterase* / metabolism |
| IF | 2.622 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |