論文 - 詳細
| RRC ID | 87637 |
|---|---|
| 著者 | Waghmare I, Page-McCaw PS, Page-McCaw A. |
| タイトル | Matrix metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution. |
| ジャーナル | Mol Biol Cell |
| Abstract |
Cell-surface glypicans distribute several extracellular ligands, including the Wnts, which are secreted to function at short and long range in a tissue. The Drosophila glypican Dally-like protein (Dlp) interacts with Wnts to inhibit short-range Wnt signaling and promote long-range signaling by the Drosophila Wnt1, Wingless (Wg). Dlp-dependent long-range Wg distribution in the fly ovary is attenuated by metalloproteinase 2 (Mmp2). Here, we report that Mmp2 destabilizes cell-surface Dlp, causing it to be internalized. Further, after Mmp2 cleavage, Dlp sequesters more Wg, suggesting that cleaved Dlp removes Wg from the extracellular space to limit its availability for signaling. Based on these and our previous results, we propose that coordinated activities of uncleaved and cleaved Dlp regulate proper extracellular Wg distribution. Overall, this study identifies the molecular basis of protease-mediated inhibition of a cell-surface glypican to modulate ligand distribution and function. |
| 巻・号 | 36(12) |
| ページ | br32 |
| 公開日 | 2025-12-1 |
| DOI | 10.1091/mbc.E22-09-0434 |
| PMID | 41091577 |
| PMC | PMC12636523 |
| MeSH | Animals Drosophila / metabolism Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Female Glypicans* / metabolism Matrix Metalloproteinase 2* / metabolism Ovary / metabolism Proteoglycans Signal Transduction Wnt Signaling Pathway Wnt1 Protein* / metabolism |
| IF | 3.791 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115031 |