論文 - 詳細
| RRC ID | 87643 |
|---|---|
| 著者 | Inagaki S, Wada H, Itabashi T, Itakura Y, Nakagawa R, Chen L, Murata K, Iwane AH, Hayashi S. |
| タイトル | Endoplasmic reticulum patterns insect cuticle nanostructure. |
| ジャーナル | J Cell Biol |
| Abstract |
Insect cuticles with nano-level structures exhibit functional surface properties such as the photonic nanocrystal of the butterfly wing scale with structural color and the corneal nipple arrays of superhydrophobic compound eye lens. Despite the enormous influence the cuticle has had on biomimetic industrial applications, cellular mechanisms of cuticular nanopatterning remain poorly understood. Drosophila gore-tex/Osiris23 (gox) controls the formation of nanopores, with a molecular filtering function, on the olfactory organs. Here we used 3D electron microscopy imaging of entire hair structures to show that nanopore is formed through a novel process of bidirectional interaction of the ER and the plasma membrane trafficking. ER-resident protein Gox stimulates ER-phagy through regulation of Ref(2)P, the fly counterpart of the autophagy protein p62/SQSTM1, and initiates endocytosis. Dynamin on the plasma membrane completes endocytosis and sustains ER-phagy. The repurposing of ER-phagy for plasma membrane remodeling and the fabrication of nanoscale ECM structures sheds light on the nanopatterning mechanism of insect cuticles and their genetic control. |
| 巻・号 | 225(2) |
| 公開日 | 2026-2-2 |
| DOI | 10.1083/jcb.202503127 |
| PII | 278764 |
| PMID | 41474612 |
| PMC | PMC12755865 |
| MeSH | Animals Cell Membrane / metabolism Cell Membrane / ultrastructure Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Drosophila melanogaster* / ultrastructure Dynamins / metabolism Endocytosis Endoplasmic Reticulum* / metabolism Endoplasmic Reticulum* / ultrastructure Nanostructures* / chemistry Nanostructures* / ultrastructure |
| IF | 8.811 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 53 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.6 |
| リソース情報 | |
| ショウジョウバエ | DGRC#106754 DGRC#119948 DGRC#119949 DGRC#119950 DGRC#119951 |