論文 - 詳細
| RRC ID | 87683 |
|---|---|
| 著者 | Rajan SG, Nacke LM, Lombardo JN, Manuchehrfar F, Wong K, Kanabar P, Somodji EA, Garcia J, Maienschein-Cline M, Liang J, Saxena A. |
| タイトル | Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis. |
| ジャーナル | Stem Cell Reports |
| Abstract |
Olfactory neurogenesis occurs throughout the lives of vertebrates, including in humans, and relies on the continuous differentiation and integration of neurons into a complex network. How progenitor cells convert fluctuations in cell-cell signaling into streamlined fate decisions over both space and time is poorly understood. Here, we track multicellular dynamics in the zebrafish olfactory epithelium, undertake targeted perturbations, and find that neurogenesis is driven by mutual antagonism between Notch signaling and insulinoma-associated 1a (Insm1a) that is responsive to inter-organ retinoic acid signaling. Single-cell analysis reveals that olfactory neurons emerge from transient groups of cells termed cellular neighborhoods. Stochastic modeling shows that neighborhood self-assembly is maintained by a tightly regulated bistable toggle switch. Differentiating cells migrate apically in response to brain-derived neurotrophic factor (BDNF) to take up residence as mature sensory neurons. Cumulatively, these findings reveal how stochastic signaling networks spatiotemporally regulate a balance between progenitors and derivatives, driving sustained neurogenesis in an intricate organ system. |
| 巻・号 | 20(9) |
| ページ | 102575 |
| 公開日 | 2025-9-9 |
| DOI | 10.1016/j.stemcr.2025.102575 |
| PII | S2213-6711(25)00179-1 |
| PMID | 40614732 |
| PMC | PMC12447343 |
| MeSH | Animals Brain-Derived Neurotrophic Factor / metabolism Cell Differentiation Neural Stem Cells* / cytology Neural Stem Cells* / metabolism Neurogenesis* Olfactory Mucosa* / cytology Olfactory Mucosa* / metabolism Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / metabolism Receptors, Notch / metabolism Signal Transduction Stem Cell Niche* Stem Cells* / cytology Stem Cells* / metabolism Tretinoin / metabolism Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 6.032 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 43 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(OMP2k :lyn-mRFP)rw035 |