| RRC ID |
87683
|
| 著者 |
Rajan SG, Nacke LM, Lombardo JN, Manuchehrfar F, Wong K, Kanabar P, Somodji EA, Garcia J, Maienschein-Cline M, Liang J, Saxena A.
|
| タイトル |
Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis.
|
| ジャーナル |
Stem Cell Reports
|
| Abstract |
Olfactory neurogenesis occurs throughout the lives of vertebrates, including in humans, and relies on the continuous differentiation and integration of neurons into a complex network. How progenitor cells convert fluctuations in cell-cell signaling into streamlined fate decisions over both space and time is poorly understood. Here, we track multicellular dynamics in the zebrafish olfactory epithelium, undertake targeted perturbations, and find that neurogenesis is driven by mutual antagonism between Notch signaling and insulinoma-associated 1a (Insm1a) that is responsive to inter-organ retinoic acid signaling. Single-cell analysis reveals that olfactory neurons emerge from transient groups of cells termed cellular neighborhoods. Stochastic modeling shows that neighborhood self-assembly is maintained by a tightly regulated bistable toggle switch. Differentiating cells migrate apically in response to brain-derived neurotrophic factor (BDNF) to take up residence as mature sensory neurons. Cumulatively, these findings reveal how stochastic signaling networks spatiotemporally regulate a balance between progenitors and derivatives, driving sustained neurogenesis in an intricate organ system.
|
| 巻・号 |
20(9)
|
| ページ |
102575
|
| 公開日 |
2025-9-9
|
| DOI |
10.1016/j.stemcr.2025.102575
|
| PII |
S2213-6711(25)00179-1
|
| PMID |
40614732
|
| PMC |
PMC12447343
|
| MeSH |
Animals
Brain-Derived Neurotrophic Factor / metabolism
Cell Differentiation
Neural Stem Cells* / cytology
Neural Stem Cells* / metabolism
Neurogenesis*
Olfactory Mucosa* / cytology
Olfactory Mucosa* / metabolism
Olfactory Receptor Neurons / cytology
Olfactory Receptor Neurons / metabolism
Receptors, Notch / metabolism
Signal Transduction
Stem Cell Niche*
Stem Cells* / cytology
Stem Cells* / metabolism
Tretinoin / metabolism
Zebrafish
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism
|
| IF |
6.032
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(OMP2k :lyn-mRFP)rw035 |
