論文 - 詳細
| RRC ID | 87704 |
|---|---|
| 著者 | Katsumura T, Sato S, Yamashita K, Oda S, Gakuhari T, Tanaka S, Fujitani K, Nishimaki T, Imai T, Yoshiura Y, Takeshima H, Hashiguchi Y, Sekita Y, Mitani H, Ogawa M, Takeuchi H, Oota H. |
| タイトル | DNA methylation site loss for plasticity-led novel trait genetic fixation. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Phenotypic plasticity allows organisms to adapt traits in response to environmental changes, yet the molecular basis by which such plastic traits become genetically fixed remains unclear. Here, we investigated gut-length plasticity in medaka fish (Oryzias latipes) through genome-wide methylation profiling, CRISPR/Cas9-mediated deletion, and population genomic analyses. We found that seasonal methylation of CpG sites upstream of the Plxnb3 is correlated with gut-length plasticity, and deletion of this region abolishes plasticity. Additionally, standing variation in Ppp3r1 is associated with genetically fixed longer gut length in populations lacking plasticity. These results suggest that loss of epigenetic regulation via CpG site reduction triggers the genetic fixation of novel traits. Our findings provide molecular evidence linking epigenetic plasticity and genetic assimilation, advancing understanding of plasticity-led evolution in natural populations. |
| 巻・号 | 123(13) |
| ページ | e2534817123 |
| 公開日 | 2026-3-31 |
| DOI | 10.1073/pnas.2534817123 |
| PMID | 41880574 |
| PMC | PMC13037885 |
| MeSH | Adaptation, Physiological* / genetics Animals CRISPR-Cas Systems CpG Islands / genetics DNA Methylation* Epigenesis, Genetic Evolution, Molecular* Female Fish Proteins / genetics Gastrointestinal Tract / anatomy & histology Male Organ Size / genetics Oryzias* / anatomy & histology Oryzias* / genetics Oryzias* / physiology Phenotype Seasons |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 44 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 37.1 |
| リソース情報 | |
| メダカ | |