論文 - 詳細
| RRC ID | 87705 |
|---|---|
| 著者 | Nishiike Y, Maki S, Miyazoe D, Nakasone K, Kamei Y, Todo T, Ishikawa-Fujiwara T, Ohno K, Usami T, Nagahama Y, Okubo K. |
| タイトル | Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka. |
| ジャーナル | Elife |
| Abstract |
In rodents, estrogens aromatized from androgens in the brain are essential for the development of male-typical behaviors. In many other vertebrates, including humans and teleost fish, however, androgens facilitate these behaviors directly via the androgen receptor without aromatization into estrogens. Here, we report that mutagenesis-derived male medaka fish lacking Cyp19a1b (a subtype of aromatase predominantly expressed in the brain) exhibit severely impaired male-typical mating and aggression, despite elevated brain androgen levels. These phenotypes can be rescued by estrogen administration, indicating that brain-derived estrogens are pivotal for male-typical behaviors even in teleosts. Our results further suggest that these estrogens facilitate male-typical behaviors by potentiating androgen action in the brain via the direct stimulation of androgen receptor transcription. Taken together, these findings reveal a previously unappreciated mode of action of brain-derived estrogens in facilitating male-typical behaviors. |
| 巻・号 | 13 |
| 公開日 | 2026-1-13 |
| DOI | 10.7554/eLife.97106 |
| PII | 97106 |
| PMID | 41527437 |
| PMC | PMC12799210 |
| MeSH | Aggression Animals Aromatase / genetics Aromatase / metabolism Brain* / metabolism Estrogens* / metabolism Male Oryzias* / physiology Receptors, Androgen* / metabolism Sexual Behavior, Animal* Signal Transduction* |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | d-rR/TOKYO olova36n18 ola1-111G01 ola1-192H15 |