論文 - 詳細
| RRC ID | 87720 |
|---|---|
| 著者 | Welz B, Pierotti S, Fitzgerald T, Thumberger T, Suzuki R, Watson P, Fuss J, Cordeiro da Trindade T, Defranoux F, Ferreira M, Naruse K, Loosli F, Gierten J, Wittbrodt J, Birney E. |
| タイトル | Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model. |
| ジャーナル | Cell Genom |
| Abstract |
Phenotypic variation arises from interactions between genetic and environmental factors, but disentangling these effects for complex traits remains challenging in observational cohorts like human biobanks. Model organisms with controlled genetic and environmental variation complement human studies in analyzing higher-order effects such as gene-by-environment (G×E) interactions, dominance, and epistasis. We utilized 76 medaka strains from the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel to compare heart rate plasticity across temperatures. An F2 segregation analysis identified 16 quantitative trait loci (QTLs), many exhibiting dominance, G×E, G×G, and G×G×E interactions. We experimentally validated four candidate genes, revealing temperature-sensitive heart rate effects. Finally, we simulated how genome-wide association study (GWAS) discovery power depends on statistical model choice. Our results suggest that the limited detection of non-additive effects in human GWASs stems from current study designs and sample sizes. This work demonstrates the value of controlled model organism studies for dissecting complex trait genetics and informing association study design. |
| ページ | 101164 |
| 公開日 | 2026-2-10 |
| DOI | 10.1016/j.xgen.2026.101164 |
| PII | S2666-979X(26)00026-1 |
| PMID | 41672067 |
| PMC | PMC13174225 |
| MeSH | Animals Epistasis, Genetic* Gene-Environment Interaction* Genome-Wide Association Study Heart Rate / genetics Humans Oryzias* / genetics Phenotype Quantitative Trait Loci / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | WS1177-NIBB |