論文 - 詳細
| RRC ID | 87972 |
|---|---|
| 著者 | Dennis N, Vazquez-Prada M, Freeman LM, Xue F, White LJ, Karamalegos AA, Sullivan WG, Kudzminkaite B, Brown I, Hiscock JR, Ezcurra M. |
| タイトル | A microbial community that alters mitochondrial morphology and age-related motor function in C. elegans. |
| ジャーナル | iScience |
| Abstract |
Across diverse taxa, the composition of the microbiota is associated with host fitness. A mechanistic understanding of how microbial communities influence host physiology could lead to microbiota-based interventions for lifelong health. Here, we have developed a host-microbiota model system consisting of the model organism C. elegans combined with a defined natural microbiota (DefNatMta) consisting of 11 bacterial strains isolated from wild C. elegans to study natural host-microbiota interactions in the laboratory. We show that DefNatMta persists in the C. elegans gut, forming a stable and distinct gut microbiota. Utilizing this host-microbiota system, we find that DefNatMta affects age-related motility and protects against age-related decline in motor function. DefNatMta acts by altering metabolism and mitochondrial network dynamics in muscle and requires dynamin-related protein 1 (DRP-1), a regulator of mitochondrial fission to protect against age-related motility decline. Our findings are consistent with microbe-mitochondria communication affecting age-related muscle function. |
| 巻・号 | 28(12) |
| ページ | 114128 |
| 公開日 | 2025-12-19 |
| DOI | 10.1016/j.isci.2025.114128 |
| PII | S2589-0042(25)02389-2 |
| PMID | 41438044 |
| PMC | PMC12721190 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1108 |