論文 - 詳細
| RRC ID | 87993 |
|---|---|
| 著者 | Lamb R, Scales M, Watkins J, Werner M, Cherra SJ 3rd. |
| タイトル | A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway. |
| ジャーナル | Development |
| Abstract |
Small G proteins coordinate the development of nerve terminals. The activity of G proteins is finely tuned by GTPase regulatory proteins. Previously, we have observed that PXF-1, a Caenorhabditis elegans GTPase regulatory protein, is required for the function of cholinergic motor neurons. Here, we investigated how PXF-1 coordinates the development of presynaptic terminals at the molecular level. We observed that PXF-1 acts through RAP-1 to promote synapse development. Subsequently, we found that pxf-1 mutants display a reduction in RAC-2 activity, which is required for cholinergic synapse development. We observed that RAC-2 acts downstream of RAP-1. Finally, we identified a physical interaction between RAP-1 and TIAM-1, a Rac guanine exchange factor, which links PXF-1 function to the presynaptic actin cytoskeleton through RAC-2 activation. These findings highlight how small G protein signaling pathways interact to coordinate the development of presynaptic terminals. |
| 巻・号 | 152(16) |
| 公開日 | 2025-8-15 |
| DOI | 10.1242/dev.204678 |
| PII | 368770 |
| PMID | 40748210 |
| PMC | PMC12448318 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Guanine Nucleotide Exchange Factors* / genetics Guanine Nucleotide Exchange Factors* / metabolism Mutation / genetics PDZ Domains Presynaptic Terminals / metabolism Signal Transduction* / physiology Synapses* / metabolism rac GTP-Binding Proteins* / metabolism rap GTP-Binding Proteins* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1556 |