論文 - 詳細
| RRC ID | 88031 |
|---|---|
| 著者 | Park S, Jin Y, Chisholm AD. |
| タイトル | Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration. |
| ジャーナル | Genetics |
| Abstract |
Neurons maintain their morphology over prolonged periods of adult life with limited regenerative capacity. Among the various factors that shape neuronal morphology, lipids function as membrane components, signaling molecules, and regulators of synaptic plasticity. Here, we tested genes involved in phospholipid biosynthesis and identified their roles in axon regrowth and maintenance. CEPT-2 and EPT-1 are enzymes catalyzing the final steps in the de novo phospholipid synthesis (Kennedy) pathway. Loss of function mutants of cept-2 or ept-1 show reduced axon regrowth and failure to maintain axon morphology. We demonstrate that CEPT-2 is required cell-autonomously to prevent age-related axonal morphology defects. We further investigated genetic interactions of cept-2 or ept-1 with dip-2, a conserved regulator of lipid metabolism that affects axon morphology maintenance and regrowth after injury. Loss-of-function in dip-2 led to suppression of axon regrowth defects observed in either cept-2 or ept-2 mutants, suggesting that DIP-2 acts to counterbalance phospholipid synthesis. Our findings reveal the genetic regulation of lipid metabolism as critical for axon maintenance following injury and during aging. |
| 巻・号 | 231(1) |
| 公開日 | 2025-9-3 |
| DOI | 10.1093/genetics/iyaf122 |
| PII | 8173643 |
| PMID | 40557979 |
| PMC | PMC12406002 |
| MeSH | Aging* / genetics Aging* / metabolism Animals Axons* / metabolism Axons* / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Lipid Metabolism Nerve Regeneration* / genetics Neurons* / metabolism Phospholipids* / biosynthesis |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3093 tm1011 tm4369 tm5755 tm5011 tm5741 |