論文 - 詳細
| RRC ID | 88036 |
|---|---|
| 著者 | Zhang Y, Shi Y, Zeng K, Chen L, Gao S. |
| タイトル | Hierarchical competing inhibition circuits govern motor stability in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Stable movement and efficient motor transition are both crucial for animals to navigate their environments, yet the neural principles underlying these abilities are not fully understood. In free-moving Caenorhabditis elegans, sustained forward locomotion is occasionally interrupted by backward movements, which are believed to result from reciprocal inhibition between the interneurons AVB and AVA. Here, we discovered that hierarchical competing inhibition circuits stabilize spontaneous movement and ensure motor transition. We found that the modulatory interneuron PVP activated AVB to maintain forward locomotion while inhibiting AVA to prevent backward movement. Another interneuron, DVC activates AVA and forms a disinhibition circuit that inhibits PVP, thereby relieving PVP's inhibition of AVA and facilitating backward movement. Notably, these asymmetrical circuit motifs create a higher-order competing inhibition that likely sharpens the motor transition. We also identified cholinergic and glutamatergic synaptic mechanisms underlying these circuits. This study elucidates a key neural principle that controls motor stability in C. elegans. |
| 巻・号 | 16(1) |
| ページ | 4405 |
| 公開日 | 2025-5-12 |
| DOI | 10.1038/s41467-025-59668-4 |
| PII | 10.1038/s41467-025-59668-4 |
| PMID | 40355468 |
| PMC | PMC12069549 |
| MeSH | Animals Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Interneurons* / physiology Locomotion* / physiology Motor Neurons / physiology Neural Inhibition* / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| 線虫 | tm3268 tm3172 tm3506 |