Reference - Detail
| RRC ID | 88060 |
|---|---|
| Author | Li KUR, Lo WK, Yang M, Wang C, Lau CY, Lee JC, Zheng C. |
| Title | Microbacterium diet rich in branched chain fatty acids promotes lipid droplet enlargement and impacts organismal health in C. elegans. |
| Journal | Cell Rep |
| Abstract |
Considerable amounts of branched chain fatty acids (BCFAs) are present in the human diet from beef and dairy products. BCFAs can also be produced by the human gut microbiota and synthesized from branched chain amino acids. However, the physiological impact of a BCFA-rich diet on lipid metabolism and organismal health is unclear. In this study, by screening a collection of dietary bacteria, we find that the BCFA-rich Microbacterium diet causes the formation of supersized LDs and delays development, reduces brood size, and shortens the lifespan of Caenorhabditis elegans. The high-BCFA diet downregulates argk-1/creatine kinase to inhibit the AMPK pathway and β-oxidation and upregulates fat-7/desaturase to promote the accumulation of PUFAs, which enhances lipogenesis and LD expansion. We also isolate a gain-of-function mutation in scav-4/CD36, which enhances BCFA absorption and exacerbates BCFA-induced LD enlargement, demonstrating that host genetic variation in a fatty acid transporter could influence the susceptibility to a high-BCFA diet. |
| Volume | 44(10) |
| Pages | 116292 |
| Published | 2025-10-28 |
| DOI | 10.1016/j.celrep.2025.116292 |
| PII | S2211-1247(25)01063-0 |
| PMID | 40960936 |
| MeSH | Actinobacteria* / metabolism Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / microbiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Diet* Fatty Acids* / metabolism Lipid Droplets* / metabolism Lipid Metabolism Lipogenesis |
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| The most frequently cited source | |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm4221 tm331 tm1011 tm420 |