論文 - 詳細
| RRC ID | 88142 |
|---|---|
| 著者 | Li G, Wu Y, Huang X, Du M, Tang H. |
| タイトル | A gut-brain-gut axis orchestrates host responses counteracting microbiome-induced iron insufficiency. |
| ジャーナル | EMBO J |
| Abstract |
The brain monitors changes in the gut microbiome to maintain health, but the impact of specific bacterial alterations, as well as the underlying mechanisms, remains largely unclear. Here, we discovered an unexpected neuronal regulation of iron metabolism, mediating the neuronal surveillance of gut bacterial activity in C. elegans. Specifically, through a genome-wide screen, we identified 29 E. coli genes, mainly linked to metabolism regulation, whose inactivation could increase dopamine and serotonin biosynthesis in C. elegans head neurons. These neurons respond to the lack of respiratory chain genes in E. coli in the gut by perceiving intestinal mitochondrial impairment resulting from bacterial-induced reduction in host labile iron levels. Such neuronal responses subsequently promote intestinal ferritin-1 expression to counteract bacterially induced labile iron reduction, thus maintaining mitochondrial function. Our findings reveal how alterations in bacterial metabolism can elevate dopamine and serotonin levels in the host brain, demonstrating that the nervous system not only senses microbiome-caused changes in the gut but also feeds back to revert them. |
| 巻・号 | 44(24) |
| ページ | 7590-7619 |
| 公開日 | 2025-12-1 |
| DOI | 10.1038/s44318-025-00619-6 |
| PII | 10.1038/s44318-025-00619-6 |
| PMID | 41184590 |
| PMC | PMC12705764 |
| MeSH | Animals Brain* / metabolism Brain-Gut Axis* Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / microbiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Dopamine / biosynthesis Dopamine / metabolism Escherichia coli* / genetics Escherichia coli* / metabolism Gastrointestinal Microbiome* Iron* / metabolism Mitochondria / metabolism Neurons / metabolism Serotonin / biosynthesis Serotonin / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.2 |
| リソース情報 | |
| 線虫 | tm351 |