Reference - Detail
| RRC ID | 88146 |
|---|---|
| Author | Demirbas B, Filina O, Louisse T, Natarajan A, Goos Y, Sánchez-Romero MA, Olmedo M, van Zon JS. |
| Title | Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth. |
| Journal | Nat Commun |
| Abstract |
Insulin signaling is the core pathway regulating body growth, but the dynamics of insulin signaling across an organism has not been studied experimentally. By imaging C. elegans larvae in microchambers, we follow the key insulin signaling step, DAF-16/FOXO nuclear translocation, at cellular level throughout the body. We show that under constant stress, translocation occurs in stochastic pulses, but with each translocation pulse occurring near-simultaneously in all cells. Pulsatile DAF-16/FOXO translocation is correlated with growth, as periods of long or frequent pulses coincide with bouts of growth arrest, and short, infrequent pulses with body growth, while the animal's ability to arrest growth is lost in daf-16/FOXO mutants. Organism-wide coordination of DAF-16/FOXO translocation pulses might thus be important to ensure uniformity of body growth, with potential implications for understanding tissue- and body-wide coordination of insulin-dependent processes also in humans. |
| Volume | 16(1) |
| Pages | 11273 |
| Published | 2025-12-11 |
| DOI | 10.1038/s41467-025-66164-2 |
| PII | 10.1038/s41467-025-66164-2 |
| PMID | 41381467 |
| PMC | PMC12717096 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / growth & development Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Nucleus* / metabolism Forkhead Transcription Factors* / genetics Forkhead Transcription Factors* / metabolism Insulin* / metabolism Larva / growth & development Larva / metabolism Mutation Protein Transport Signal Transduction* |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 14 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| C.elegans | tm3103 tm1944 |