論文 - 詳細
| RRC ID | 88196 |
|---|---|
| 著者 | Wu X, Briseño CG, Grajales-Reyes GE, Haldar M, Iwata A, Kretzer NM, Kc W, Tussiwand R, Higashi Y, Murphy TL, Murphy KM. |
| タイトル | Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Dendritic cells (DCs) and monocytes develop from a series of bone-marrow-resident progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an E-box-binding protein associated with epithelial-mesenchymal transition and is widely expressed among hematopoietic lineages. Previously, we observed that Zeb2 expression is differentially regulated in progenitors committed to classical DC (cDC) subsets in vivo. Using systems for inducible gene deletion, we uncover a requirement for Zeb2 in the development of Ly-6Chi monocytes but not neutrophils, and we show a corresponding requirement for Zeb2 in expression of the M-CSF receptor in the bone marrow. In addition, we confirm a requirement for Zeb2 in development of plasmacytoid DCs but find that Zeb2 is not required for cDC2 development. Instead, Zeb2 may act to repress cDC1 progenitor specification in the context of inflammatory signals. |
| 巻・号 | 113(51) |
| ページ | 14775-14780 |
| 公開日 | 2016-12-20 |
| DOI | 10.1073/pnas.1611408114 |
| PII | 1611408114 |
| PMID | 27930303 |
| PMC | PMC5187668 |
| MeSH | Animals Bone Marrow / metabolism CD8-Positive T-Lymphocytes / cytology Cell Lineage Cytoplasm / metabolism Dendritic Cells / cytology* Female Flow Cytometry Gene Deletion Gene Expression Profiling Gene Expression Regulation* Inflammation Integrases / metabolism Male Mice Monocytes / cytology* Neutrophils / cytology Neutrophils / metabolism Zinc Finger E-box Binding Homeobox 2 / genetics* Zinc Finger E-box Binding Homeobox 2 / physiology* |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01924 |