Reference - Detail
| RRC ID | 88717 |
|---|---|
| Author | Takeuchi T, Miyauchi E, Nakanishi Y, Ito Y, Kato T, Yaguchi K, Kawasumi M, Tachibana N, Ito A, Shimamoto S, Matsuyama A, Sasaki N, Kimura I, Ohno H. |
| Title | Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates. |
| Journal | Cell Metab |
| Abstract |
Effective approaches to preventing and treating obesity are urgently needed. Although current strategies primarily focus on direct modulation of host metabolism, another promising approach may involve limiting nutrient availability through regulation of the gut microbiota, which links diet and host physiology. Here, we report that acetylated cellulose (AceCel), which markedly alters gut bacterial composition and function, reduces body mass gain in both wild-type and obese mice. AceCel limits carbohydrate oxidation and promotes fatty acid oxidation in the host liver in a microbiota-dependent manner. We further show that acetate enhances carbohydrate fermentation by the gut commensal Bacteroides thetaiotaomicron, depleting host-accessible simple sugars in the gut of AceCel-fed mice. These findings highlight the potential of AceCel as a prebiotic that regulates carbohydrate metabolism in both bacteria and host, offering promise as a therapeutic strategy for obesity. |
| Volume | 37(8) |
| Pages | 1682-1697.e6 |
| Published | 2025-8-5 |
| DOI | 10.1016/j.cmet.2025.04.013 |
| PII | S1550-4131(25)00223-2 |
| PMID | 40381616 |
| MeSH | Acetylation Animals Bacteroides thetaiotaomicron / drug effects Bacteroides thetaiotaomicron / metabolism Carbohydrate Metabolism* / drug effects Cellulose* / analogs & derivatives Cellulose* / pharmacology Fatty Acids / metabolism Gastrointestinal Microbiome* / drug effects Liver / metabolism Male Mice Mice, Inbred C57BL Mice, Obese Obesity / metabolism Obesity / microbiology Prebiotics Weight Gain* / drug effects |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 94 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM5827 JCM5824 JCM9498 |