論文 - 詳細
| RRC ID | 89120 |
|---|---|
| 著者 | Podnar E, Dendinovic K, Danevčič T, Lories B, Kovačec E, Steenackers H, Mandic-Mulec I. |
| タイトル | Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway. |
| ジャーナル | ISME J |
| Abstract |
The interactions between beneficial bacteria and pathogens are understudied. Here we investigate the interactions between the probiotic strain Bacillus subtilis PS-216 and the pathogen Salmonella Typhimurium SL1344. We show here that the sporulation of B. subtilis is impaired when it competes with S. Typhimurium in a nutrient-depleted medium. The sporulation impairment in B. subtilis is mediated by the sigma factor B (SigB)-dependent general stress response, as the ΔsigB mutant remains blind to manipulative cues from S. Typhimurium. Furthermore, we show that decreased sporulation frequency in B. subtilis depends on cell-cell contact between the two species involving the S. Typhimurium Type VI Secretion System, whereas B. subtilis uses the SigB-dependent response to trade spore quantity for higher spore quality. |
| 巻・号 | 19(1) |
| 公開日 | 2025-1-2 |
| DOI | 10.1093/ismejo/wraf052 |
| PII | 8082934 |
| PMID | 40098255 |
| PMC | PMC11994997 |
| MeSH | Bacillus subtilis* / genetics Bacillus subtilis* / growth & development Bacillus subtilis* / physiology Bacterial Proteins* / genetics Bacterial Proteins* / metabolism Gene Expression Regulation, Bacterial Microbial Interactions* Salmonella typhimurium* / genetics Salmonella typhimurium* / growth & development Salmonella typhimurium* / physiology Sigma Factor* / genetics Sigma Factor* / metabolism Spores, Bacterial* / growth & development Spores, Bacterial* / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| 原核生物(枯草菌) | BKE24610 |