Reference - Detail
| RRC ID | 89126 |
|---|---|
| Author | Kano T, Ishikawa K, Imai L, Furuta K, Kaito C. |
| Title | RpoB H481Y Rifampicin Resistance Mutation-Associated Oxidative Stress Sensitivity Reduces the Virulence of Staphylococcus aureus. |
| Journal | Microbiol Immunol |
| Abstract |
In this study, we have established a Staphylococcus aureus RpoB H481Y mutant strain and demonstrated that it is sensitive to menadione or hydrogen peroxide-induced oxidative stress and exhibits reduced virulence against a silkworm infection model. Furthermore, the reduced virulence of the RpoB H481Y mutant was abrogated in the presence of N-acetylcysteine, a reactive oxygen species scavenger. These results suggest that oxidative stress sensitivity caused by the RpoB H481Y rifampicin resistance mutation attenuates the virulence of S. aureus. |
| Volume | 69(2) |
| Pages | 128-131 |
| Published | 2025-2-1 |
| DOI | 10.1111/1348-0421.13190 |
| PMID | 39616518 |
| PMC | PMC11789207 |
| MeSH | Acetylcysteine / pharmacology Animals Anti-Bacterial Agents* / pharmacology Bacterial Proteins* / genetics Bacterial Proteins* / metabolism DNA-Directed RNA Polymerases* / genetics Disease Models, Animal Drug Resistance, Bacterial* / genetics Hydrogen Peroxide / pharmacology Mutation Oxidative Stress* / drug effects Rifampin* / pharmacology Staphylococcal Infections / microbiology Staphylococcus aureus* / drug effects Staphylococcus aureus* / genetics Staphylococcus aureus* / pathogenicity Virulence / genetics Vitamin K 3 / pharmacology |
| Resource | |
| Prokaryotes E. coli | |