Reference - Detail
| RRC ID | 89202 |
|---|---|
| Author | Roberts H, Fang Y, Quinn K, Hill T, Peck MR, Bartke A, Hascup KN, Hascup ER. |
| Title | Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease. |
| Journal | J Alzheimers Dis |
| Abstract |
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APPNL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APPNL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes. |
| Volume | 105(1) |
| Pages | 56-61 |
| Published | 2025-5-1 |
| DOI | 10.1177/13872877251325878 |
| PMID | 40138433 |
| PMC | PMC12376845 |
| MeSH | Alzheimer Disease* / genetics Alzheimer Disease* / mortality Amyloid beta-Protein Precursor* / genetics Animals Disease Models, Animal Female Humans Longevity* / genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Presenilin-1* / genetics Sex Characteristics* |
| IF | 3.909 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Mice | RBRC06343 |