| RRC ID |
89202
|
| Author |
Roberts H, Fang Y, Quinn K, Hill T, Peck MR, Bartke A, Hascup KN, Hascup ER.
|
| Title |
Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease.
|
| Journal |
J Alzheimers Dis
|
| Abstract |
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APPNL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APPNL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
|
| Volume |
105(1)
|
| Pages |
56-61
|
| Published |
2025-5-1
|
| DOI |
10.1177/13872877251325878
|
| PMID |
40138433
|
| PMC |
PMC12376845
|
| MeSH |
Alzheimer Disease* / genetics
Alzheimer Disease* / mortality
Amyloid beta-Protein Precursor* / genetics
Animals
Disease Models, Animal
Female
Humans
Longevity* / genetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Presenilin-1* / genetics
Sex Characteristics*
|
| Resource |
| Mice |
RBRC06343 |
