論文 - 詳細
| RRC ID | 89202 |
|---|---|
| 著者 | Roberts H, Fang Y, Quinn K, Hill T, Peck MR, Bartke A, Hascup KN, Hascup ER. |
| タイトル | Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease. |
| ジャーナル | J Alzheimers Dis |
| Abstract |
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APPNL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APPNL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes. |
| 巻・号 | 105(1) |
| ページ | 56-61 |
| 公開日 | 2025-5-1 |
| DOI | 10.1177/13872877251325878 |
| PMID | 40138433 |
| PMC | PMC12376845 |
| MeSH | Alzheimer Disease* / genetics Alzheimer Disease* / mortality Amyloid beta-Protein Precursor* / genetics Animals Disease Models, Animal Female Humans Longevity* / genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Presenilin-1* / genetics Sex Characteristics* |
| IF | 3.909 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 実験動物マウス | RBRC06343 |