Reference - Detail
| RRC ID | 89263 |
|---|---|
| Author | Fuwa TJ, Hori K, Sasamura T, Higgs J, Baron M, Matsuno K. |
| Title | The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. |
| Journal | Mol Genet Genomics |
| Abstract |
Notch (N) is a single-pass transmembrane receptor. The N signaling pathway is an evolutionarily conserved mechanism that controls various cell-specification processes. Drosophila Deltex (Dx), a RING-domain E3 ubiquitin ligase, binds to the N intracellular domain, promotes N's endocytic trafficking to late endosomes, and was proposed to activate Suppressor of Hairless [Su(H)]-independent N signaling. However, it has been difficult to evaluate the importance of dx, because no null mutant of a dx family gene has been available in any organism. Here, we report the first null mutant allele of Drosophila dx. We found that dx was involved only in the subsets of N signaling, but was not essential for it in any developmental context. A strong genetic interaction between dx and Su(H) suggested that dx might function in Su(H)-dependent N signaling. Our epistatic analyses suggested that dx functions downstream of the ligands and upstream of activated Su(H). We also uncovered a novel dx activity that suppressed N signaling downstream of N. |
| Volume | 275(3) |
| Pages | 251-63 |
| Published | 2006-3-1 |
| DOI | 10.1007/s00438-005-0087-3 |
| PMID | 16395579 |
| MeSH | Animals Base Sequence DNA Primers Drosophila Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Endocytosis Membrane Proteins / genetics* Mosaicism Mutation* Receptors, Notch / metabolism* Signal Transduction* |
| IF | 2.797 |
| Altmetric score |
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#119830 |