論文 - 詳細
| RRC ID | 89665 |
|---|---|
| 著者 | Suto N, Wang MY, Morikawa S, Chung M, Tao K, Huang Z, Ikegaya Y, Takeuchi H, Kira S, Okuyama T. |
| タイトル | Neural circuits for valence updating in social memory. |
| ジャーナル | Science |
| Abstract |
Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)-basolateral amygdala (BLA)-nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1-BLA-NAc neural circuit flexibly regulates adaptive social behaviors. |
| 巻・号 | 393(6807) |
| ページ | eadx8231 |
| 公開日 | 2026-7-9 |
| DOI | 10.1126/science.adx8231 |
| PMID | 42424460 |
| MeSH | Aggression Animals Basolateral Nuclear Complex* / physiology CA1 Region, Hippocampal* / physiology Male Memory* / physiology Mice Mice, Inbred BALB C Neural Pathways* / physiology Neurons / physiology Nucleus Accumbens* / physiology Social Behavior* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 136 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 79.7 |
| リソース情報 | |
| 実験動物マウス | RBRC10322 RBRC10754 |