Reference - Detail
| RRC ID | 89665 |
|---|---|
| Author | Suto N, Wang MY, Morikawa S, Chung M, Tao K, Huang Z, Ikegaya Y, Takeuchi H, Kira S, Okuyama T. |
| Title | Neural circuits for valence updating in social memory. |
| Journal | Science |
| Abstract |
Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)-basolateral amygdala (BLA)-nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1-BLA-NAc neural circuit flexibly regulates adaptive social behaviors. |
| Volume | 393(6807) |
| Pages | eadx8231 |
| Published | 2026-7-9 |
| DOI | 10.1126/science.adx8231 |
| PMID | 42424460 |
| MeSH | Aggression Animals Basolateral Nuclear Complex* / physiology CA1 Region, Hippocampal* / physiology Male Memory* / physiology Mice Mice, Inbred BALB C Neural Pathways* / physiology Neurons / physiology Nucleus Accumbens* / physiology Social Behavior* |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 136 |
| Altmetric score changes over past 6months | 79.7 |
| Resource | |
| Mice | RBRC10322 RBRC10754 |