| RRC ID |
89665
|
| 著者 |
Suto N, Wang MY, Morikawa S, Chung M, Tao K, Huang Z, Ikegaya Y, Takeuchi H, Kira S, Okuyama T.
|
| タイトル |
Neural circuits for valence updating in social memory.
|
| ジャーナル |
Science
|
| Abstract |
Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)-basolateral amygdala (BLA)-nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1-BLA-NAc neural circuit flexibly regulates adaptive social behaviors.
|
| 巻・号 |
393(6807)
|
| ページ |
eadx8231
|
| 公開日 |
2026-7-9
|
| DOI |
10.1126/science.adx8231
|
| PMID |
42424460
|
| MeSH |
Aggression
Animals
Basolateral Nuclear Complex* / physiology
CA1 Region, Hippocampal* / physiology
Male
Memory* / physiology
Mice
Mice, Inbred BALB C
Neural Pathways* / physiology
Neurons / physiology
Nucleus Accumbens* / physiology
Social Behavior*
|
| リソース情報 |
| 実験動物マウス |
RBRC10322
RBRC10754 |
