| RRC ID |
91
|
| 著者 |
Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.
|
| タイトル |
Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker.
|
| ジャーナル |
J Cardiovasc Pharmacol
|
| Abstract |
Increased levels of endothelin-1 have been demonstrated in the ischemic brain, and endothelin receptor antagonism has been shown to improve the outcome of cerebral ischemia. However, it remains unknown what the relative receptor distribution in the brain of the spontaneously hypertensive stroke-prone rat (SHR-SP) is and whether it is changed by endothelin antagonism. The present study aimed to investigate the expression of the two endothelin receptors in the frontal cortex of SHR-SP after 12 weeks of treatment with an endothelin-A/endothelin-B dual receptor antagonist, SB209670, or saline (vehicle) starting from the prehypertensive stage (6 weeks old). A 50% increase in the endothelin-A receptor was found in the vehicle-treated brain of SHR-SP compared with that of the age-matched Wistar-Kyoto control, but endothelin antagonism reversed this upregulation completely. A 20% decrease in endothelin-B receptor was found in the vehicle-treated brain of SHR-SP compared with Wistar-Kyoto and was recovered by endothelin antagonism. This is the first study to explore the relative endothelin receptor distribution in the frontal cortex of SHR-SP at the typical hypertensive stage and changes resulting from long-term endothelin antagonism starting from the prehypertensive stage.
|
| 巻・号 |
44 Suppl 1
|
| ページ |
S156-9
|
| 公開日 |
2004-11-1
|
| DOI |
10.1097/01.fjc.0000166258.96980.23
|
| PII |
00005344-200411001-00041
|
| PMID |
15838268
|
| MeSH |
Age Factors
Animals
Antihypertensive Agents / pharmacology*
Cerebral Cortex / drug effects*
Cerebral Cortex / metabolism
Disease Models, Animal
Endothelin A Receptor Antagonists*
Endothelin B Receptor Antagonists*
Hypertension / complications
Hypertension / drug therapy*
Hypertension / metabolism
Indans / pharmacology*
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptor, Endothelin A / metabolism
Receptor, Endothelin B / metabolism
Stroke / drug therapy
Stroke / etiology
Stroke / metabolism
|
| IF |
2.598
|
| 引用数 |
2
|
|
WOS 分野
|
CARDIAC & CARDIOVASCULAR SYSTEMS
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ラット |
WKY/Ezo(strainID=568)
SHRSP/Ezo(strainID=357) |
