| RRC ID |
968
|
| Author |
Hirose K, Hashimoto A, Tamura K, Kawamura Y, Ezaki T, Sagara H, Watanabe H.
|
| Title |
DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance-determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.
|
| Journal |
Antimicrob Agents Chemother
|
| Abstract |
The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB, parC, and parE genes.
|
| Volume |
46(10)
|
| Pages |
3249-52
|
| Published |
2002-10-1
|
| DOI |
10.1128/AAC.46.10.3249-3252.2002
|
| PMID |
12234852
|
| PMC |
PMC128770
|
| MeSH |
Anti-Infective Agents / pharmacology*
DNA Gyrase / genetics*
DNA Topoisomerase IV / genetics*
Drug Resistance, Bacterial / genetics*
Fluoroquinolones
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation
Salmonella paratyphi A / drug effects*
Salmonella paratyphi A / enzymology
Salmonella paratyphi A / genetics
Salmonella typhi / drug effects*
Salmonella typhi / enzymology
Salmonella typhi / genetics
Sequence Analysis, DNA
|
| IF |
4.904
|
| Times Cited |
74
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
|
