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  • Search Condition : Filter (MeSH = Alzheimer Disease / metabolism*)
Species Resource Title
Human and Animal Cells SK-N-SH(RCB0426) Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.
DNA material Alcadein a-FLAG /pcDNA3.1(+) (RDB19587) , Alcadein b-FLAG /pcDNA3.1(+) (RDB19588) , Alcadein g-FLAG /pcDNA3.1(+) (RDB19589) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Mice RBRC02370 Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Drosophila Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
C.elegans tm1779 , tm376 Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Mice RBRC06334 YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Drosophila Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies.
Human and Animal Cells COS-7(RCB0539) TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.
Drosophila 1973R-3 Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.
Human and Animal Cells MG6(RCB2403) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
C.elegans tm1779 Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
Human and Animal Cells PC-12(RCB0009) Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β.
Human and Animal Cells anti-αB-crystallin(RCB1304) Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.
Human and Animal Cells KG-1-C(RCB0270) Eight-residue Abeta peptides inhibit the aggregation and enzymatic activity of Abeta42.
Human and Animal Cells CHO-K1(RCB0285) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
Mice RBRC02192 Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
DNA material Human ILEI / pcDNA6 (RDB13040) , Human ILEI-siRNA / pSUP (RDB13041). The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
C.elegans tm465 , tm776 REST and stress resistance in ageing and Alzheimer's disease.
Mice RBRC01390 Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
Mice RBRC00806 Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy.