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  • 検索条件 : 絞込み (MeSH = Alzheimer Disease / metabolism*)
生物種 リソース名 タイトル
ヒト・動物細胞 SK-N-SH(RCB0426) Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.
遺伝子材料 Alcadein a-FLAG /pcDNA3.1(+) (RDB19587) , Alcadein b-FLAG /pcDNA3.1(+) (RDB19588) , Alcadein g-FLAG /pcDNA3.1(+) (RDB19589) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
実験動物マウス RBRC02370 Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
ショウジョウバエ Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
線虫 tm1779 , tm376 Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
実験動物マウス RBRC06334 YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
ショウジョウバエ Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies.
ヒト・動物細胞 COS-7(RCB0539) TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.
ショウジョウバエ 1973R-3 Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.
ヒト・動物細胞 MG6(RCB2403) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
線虫 tm1779 Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
ヒト・動物細胞 PC-12(RCB0009) Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β.
ヒト・動物細胞 anti-αB-crystallin(RCB1304) Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.
ヒト・動物細胞 KG-1-C(RCB0270) Eight-residue Abeta peptides inhibit the aggregation and enzymatic activity of Abeta42.
ヒト・動物細胞 CHO-K1(RCB0285) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
実験動物マウス RBRC02192 Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
遺伝子材料 Human ILEI / pcDNA6 (RDB13040) , Human ILEI-siRNA / pSUP (RDB13041). The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
線虫 tm465 , tm776 REST and stress resistance in ageing and Alzheimer's disease.
実験動物マウス RBRC01390 Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
実験動物マウス RBRC00806 Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy.