論文 - 詳細
| RRC ID | 46649 |
|---|---|
| 著者 | Martinez-Finley EJ, Avila DS, Chakraborty S, Aschner M. |
| タイトル | Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases. |
| ジャーナル | Metallomics |
| Abstract |
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD. |
| 巻・号 | 3(3) |
| ページ | 271-9 |
| 公開日 | 2011-3-1 |
| DOI | 10.1039/c0mt00064g |
| PMID | 21210060 |
| PMC | PMC3172965 |
| MeSH | Alzheimer Disease / genetics Alzheimer Disease / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Disease Models, Animal* Metals / metabolism* Parkinson Disease / genetics Parkinson Disease / metabolism* |
| IF | 3.796 |
| 引用数 | 19 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 線虫 | tm1779 |