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  • Search Condition : Filter (MeSH = Amyotrophic Lateral Sclerosis / genetics*)
Species Resource
Zebrafish Tg(hb9:Venus) Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
C.elegans Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
C.elegans tm776 A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model.
C.elegans tm3659 A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis.
Drosophila Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Zebrafish Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.
Zebrafish Tg(Huc:Kaede) ALS-linked protein disulfide isomerase variants cause motor dysfunction.
Drosophila 9553R-3 Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
Human and Animal Cells SK-N-SH (RCB0426) Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS.
Drosophila Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Human and Animal Cells GI-1 VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.