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  • Search Condition : Filter (MeSH = Checkpoint Kinase 1)
Species Resource
C.elegans tm853 Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.
Yeast genomic library Separase-mediated cleavage of cohesin at interphase is required for DNA repair.
Yeast FY32571 Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment.
Yeast ? Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.
Yeast FY16194 , MY444 Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
Yeast S. pombe strains Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
C.elegans tm2176 ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
DNA material chk1+ (RDB02949) , crb2+ (RDB02950). Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
C.elegans tm764 , tm853 The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
Yeast FY14069 Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.
DNA material His-Xpress-RALT (RDB012225) , Flag-Chk1 (1-365) (RDB012229) , His-Xpress-RALT S250A mutant (RDB012226) , SNAP-RALT (RDB012227) , SNAP-RALT S250A mutant (RDB012228) , Flag-Chk1 (1-365) K38M mutant (RDB012230) Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.
Drosophila DGRC#206588 , DGRC#200898 , DGRC#202035 , DGRC#202883 , DGRC#202099 , ... Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.
Yeast genome library (pTN-L1) The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.
DNA material S. pombe ORFeome clone SpYFH27F12 (SPW090932) , SpYFH45G09 (SPW098153). Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.
Human and Animal Cells Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells.
Human and Animal Cells The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.
Human and Animal Cells Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
Human and Animal Cells Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells.
Human and Animal Cells Administration sequence-dependent antitumor effects of paclitaxel and 5-fluorouracil in the human gastric cancer cell line MKN45.
Human and Animal Cells Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.