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  • Search Condition : Filter (MeSH = Checkpoint Kinase 1)
Species Resource Title
Human and Animal Cells WI-38(RCB0704) DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment.
DNA material pENTR4-H1 (RDB04395) Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint.
Human and Animal Cells MKN45(RCB1001) 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.
C.elegans tm1145 The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks.
DNA material S. pombe ORFeome clone SpYFH27F12 (SPW090932) , SpYFH45G09 (SPW098153). Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.
C.elegans tm764 , tm853 The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
Human and Animal Cells HeLa-Fucci Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells.
Human and Animal Cells HL60(RCB0041) Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells.
Human and Animal Cells PC-3(RCB2145) , HSC-3(RCB1975) Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
Human and Animal Cells MC3T3-E1(RCB1126) The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.
Human and Animal Cells MC3T3-E1(RCB1126) 1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130.
Human and Animal Cells HeLa(RCB0007) Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Human and Animal Cells MKN45(RCB1001) Administration sequence-dependent antitumor effects of paclitaxel and 5-fluorouracil in the human gastric cancer cell line MKN45.
DNA material chk1+ (RDB02949) , crb2+ (RDB02950). Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
C.elegans tm2176 ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
Yeast S. pombe strains Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
Yeast FY16194 , MY444 Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
Yeast Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.
Yeast genome library (pTN-L1) The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.
Drosophila DGRC#206588 , DGRC#200898 , DGRC#202035 , DGRC#202883 , DGRC#202099 , DGRC#205625 , DGRC#201743 , DGRC#201604 , DGRC#202070 , DGRC#201318 , ... Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.