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  • 検索条件 : 絞込み (MeSH = Checkpoint Kinase 1)
生物種 リソース名 タイトル
ヒト・動物細胞 WI-38(RCB0704) DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment.
遺伝子材料 pENTR4-H1 (RDB04395) Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint.
ヒト・動物細胞 MKN45(RCB1001) 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.
線虫 tm1145 The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks.
遺伝子材料 S. pombe ORFeome clone SpYFH27F12 (SPW090932) , SpYFH45G09 (SPW098153). Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.
線虫 tm764 , tm853 The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
ヒト・動物細胞 HeLa-Fucci Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells.
ヒト・動物細胞 Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells.
ヒト・動物細胞 PC-3(RCB2145) , HSC-3(RCB1975) Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
ヒト・動物細胞 MC3T3-E1(RCB1126) The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.
ヒト・動物細胞 MC3T3-E1(RCB1126) 1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130.
ヒト・動物細胞 HeLa(RCB0007) Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
ヒト・動物細胞 MKN45(RCB1001) Administration sequence-dependent antitumor effects of paclitaxel and 5-fluorouracil in the human gastric cancer cell line MKN45.
遺伝子材料 chk1+ (RDB02949) , crb2+ (RDB02950). Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
線虫 tm2176 ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
酵母 S. pombe strains Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
酵母 FY16194 , MY444 Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
酵母 Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.
酵母 genome library (pTN-L1) The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.
ショウジョウバエ DGRC#206588 , DGRC#200898 , DGRC#202035 , DGRC#202883 , DGRC#202099 , DGRC#205625 , DGRC#201743 , DGRC#201604 , DGRC#202070 , DGRC#201318 , ... Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.