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Species Resource Title
Human and Animal Cells 1231A3(HPS0381) iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis.
Human and Animal Cells HCE-T(RCB2280) Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation.
Human and Animal Cells PANC-1(RCB2095) Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate.
Human and Animal Cells Lu99(RCB1900) , RERF-LC-AI(RCB0444) Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Human and Animal Cells CACO-2(RCB0988) , 293T(RCB2202) MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.
Human and Animal Cells Ba/F3 Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor.
Human and Animal Cells PC-9(RCB4455) Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
Human and Animal Cells KP4(RCB1005) Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
Human and Animal Cells HuCCT1(RCB1960) Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein.
Human and Animal Cells 5637(RCB1191) Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology - phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells.
Human and Animal Cells MCF7(RCB1904) Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
C.elegans Novel Findings of Anti-Filarial Drug Target and Structure-Based Virtual Screening for Drug Discovery.
Human and Animal Cells ATN-1(RCB1440) Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.
Silkworms [The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].
Silkworms Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.
Silkworms Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.
DNA material Nano-lantern clones: pYNL-N1 (RDB13323) , pYNL-C1 (RDB13324) , pCNL-N1 (RDB13325) , pCNL-C1 (RDB13326) , pONL-N1 (RDB13327) , pONL-C1 (RDB13328) , pYNL-N1_Mito (RDB13329) , pCNL-N1_Mito (RDB13330) , pONL-N1_Mito (RDB13331) , pYNL-N1_3xNLS (RDB13332) , ... Recent progress in luminescent proteins development.
Silkworms [Identification of novel therapeutically effective antibiotics using silkworm infection model].