論文 - 詳細
| RRC ID | 36366 |
|---|---|
| 著者 | Ishii K, Hamamoto H, Sekimizu K. |
| タイトル | Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies. |
| ジャーナル | Drug Discov Ther |
| Abstract |
Innate immunity acts as a front-line barrier against invading pathogens, and the majority of the components are widely conserved among species. Regulation of innate immunity is important for overcoming infections and preventing self-damaging sepsis. Using the silkworm (Bombyx mori) as an animal model, we elucidated the activation processes of innate immunity with emphasis on a multifunctional insect cytokine called paralytic peptide. Moreover, we established an ex vivo system using silkworm larval specimens to quantitatively evaluate the immunostimulatory activity of natural compounds. We observed that overactivation of innate immunity in silkworms induces tissue damage followed by host death, resembling sepsis-induced multi-organ failure in humans. Here, we summarize our recent findings and propose the usefulness of the silkworm as an animal model for studying immune regulation and for evaluating compounds with the potential to regulate innate immunity. |
| 巻・号 | 9(4) |
| ページ | 238-46 |
| 公開日 | 2015-8-1 |
| DOI | 10.5582/ddt.2015.01015 |
| PMID | 25865526 |
| MeSH | Animals Bombyx / drug effects Bombyx / immunology* Drug Discovery* Host-Pathogen Interactions* Immunity, Innate Immunologic Factors / pharmacology* Models, Animal |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
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| カイコ | |