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Species Resource Title
DNA material pMK106 (RDB08469) , pMRX-bsr-Flag-AID-Rab1B (RDB19429) , pMRX-bsr-Flag-AID-Rab5A (RDB19430) , pMRX-bsr-FLAG-OsTIR1 (RDB19431) Establishment and analysis of conditional Rab1- and Rab5-knockout cells using the auxin-inducible degron system.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain.
Drosophila DGRC#115298 Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
Drosophila DGRC#112830 Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability.
Human and Animal Cells HeLa SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
C.elegans tm2058 , tm2790 , tm2640 , tm3628 , tm3630 , tm2564 , tm1865 , tm2907 The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells.
C.elegans tm327 , tm4103 , tm2608 , tm4137 , tm2241 Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans.
C.elegans tm4275 , tm4790 , tm3622 The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.
DNA material pEF-HA-mouse MICAL-L1 (RDB15385) , pEF-Myc-mouse EHD1 (RDB15386). Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.
Drosophila Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.
C.elegans tm385 Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
C.elegans tm3536 , tm3645 Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.
C.elegans tm2241 , tm3255 , tm2991 , tm2081 , tm2095 , tm2306 , tm2058 , tm2089 , tm2466 RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.
C.elegans tm4328 SID-5 is an endosome-associated protein required for efficient systemic RNAi in C. elegans.
C.elegans tm3802 , tm2282 , tm3255 TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans.
C.elegans tm1801 , tm1275 , tm1773 Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase.
C.elegans tm4275 The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.
C.elegans tm2241 , tm1060 Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.
C.elegans dma-1(tm5159) , rab-8 (tm2526) , sec-5 (tm1413) , sec-10 (tm3437) , sec-5 (tm1443) RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization.
DNA material pco12 EGFR (RDB01276) , CSII-EF-MCS (RDB04378). ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.