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  • Search Condition : Filter (MeSH = Guanine Nucleotide Exchange Factors / genetics)
Species Resource Title
C.elegans tm4024 , tm469 Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
DNA material , Human and Animal Cells pmStr-C1-Vps9d1 (RDB19825) , pmStr-C1-Vps9d1-Y628A (YA) (RDB19826) , COS-7(RCB0539) Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
Arabidopsis / Cultured plant cells, genes pst05666 , pst18264 A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells.
DNA material C-Epac2-Y (RDB19602) The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.
Mice , Human and Animal Cells RBRC04421 , 293T(RCB2202) The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts.
Human and Animal Cells Lu99(RCB1900) , PC-9(RCB4455) Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
Lotus / Glycine pUB-GWS-GFP , pUB-GFP SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus.
Arabidopsis / Cultured plant cells, genes pda Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis.
Human and Animal Cells NRK49F(RCB0112) The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation.
Drosophila DGRC#206863 Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons.
Drosophila Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.
C.elegans tm1095 , tm2807 RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling.
Human and Animal Cells COS-7(RCB0539) Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.
C.elegans tm4024 , tm9033 , tm2143 , tm2409 , tm2241 , tm3310 DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.
Human and Animal Cells VMRC-RCW(RCB1963) Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
C.elegans tm1516 The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
DNA material pEGFP-C1-human DENN (RDB15288) , pEGFP-C1-mouse DENND1A (RDB15289) , pEGFP-C1-mouse DENND3 (RDB15290). MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
Mice RBRC01081 Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.
Rice Induced mutation lines Guanine nucleotide exchange factor 2 for Rab5 proteins coordinated with GLUP6/GEF regulates the intracellular transport of the proglutelin from the Golgi apparatus to the protein storage vacuole in rice endosperm.
C.elegans tm3203 , tm2916 , tm2926 , tm3214 Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.