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  • Search Condition : Filter (MeSH = Piperazines / pharmacology)
Species Resource Title
Human and Animal Cells MIA Paca2(RCB2094) , LU65(RCB1967) Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.
Human and Animal Cells MC3T3-E1(RCB1126) Bone Formation Ability and Cell Viability Enhancement of MC3T3-E1 Cells by Ferrostatin-1 a Ferroptosis Inhibitor of Cancer Cells.
Human and Animal Cells HeLa(RCB0007) Mitotic specific phosphorylation of serine-1212 in human DNA topoisomerase IIalpha.
Human and Animal Cells B16F10(RCB2630) Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.
Human and Animal Cells JHOC-5(RCB1520) Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
Human and Animal Cells TEN(RCB1433) The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.
Human and Animal Cells HSC-2(RCB1945) , Ca9-22(RCB1976) , SAS(RCB1974) Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Human and Animal Cells KLM-1(RCB2138) Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells.
Human and Animal Cells ACC-MESO-1(RCB2292) , ACC-MESO-4(RCB2293) Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells.
Human and Animal Cells PANC-1(RCB2095) Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation.
Human and Animal Cells 10T1/2(RCB0247) Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3.
Human and Animal Cells JHOC-7(RCB1688) Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma.
Human and Animal Cells Hep G2 Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.
Human and Animal Cells Ba/F3(RCB0805) Dual blockade of EGFR tyrosine kinase using osimertinib and afatinib eradicates EGFR‑mutant Ba/F3 cells.
Human and Animal Cells PANC-1(RCB2095) Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
DNA material pENTER-EGFR wild-type (RDB15488) , pENTER-EGFR Del19 (RDB15489) , pENTER-EGFR T790M/del19 (RDB15490) , pENTER-EGFR C797S/del19 (RDB15491) , pENTER-EGFR C797S/T790M/del19 (RDB15492) , pENTER-EGFR L858R (RDB15493) , pENTER-EGFR T790M/L858R (RDB15494) , pENTER-EGFR C797S/L858R (RDB15495) , pENTER-EGFR C797S/T790M/L858R (RDB15496). Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
DNA material R1 B - R1G (RDB13204) Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Human and Animal Cells RAW 264(RCB0535) Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B.
Human and Animal Cells K562 Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells.