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  • Search Condition : Filter (MeSH = Progranulins)
Species Resource Title
Mice RBRC02370 Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.
Human and Animal Cells MG6(RCB2403) Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Mice RBRC02370 Microglia increases the proliferation of retinal precursor cells during postnatal development.
Human and Animal Cells ATDC5(RCB0565) The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.
C.elegans tm985 A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
C.elegans tm985 The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.
Human and Animal Cells A431(RCB0202) Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats.
Mice RBRC02370 Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
Mice , Human and Animal Cells RBRC02370 , MC3T3-E1(RCB1126) Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice.
Mice RBRC02370 Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.
Mice RBRC02370 Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.
Mice RBRC02370 Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice.
C.elegans fust-1(tm4439) , pgrn-1(tm985) Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.