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  • Search Condition : Filter (MeSH = Protein Kinase Inhibitors / pharmacology)
Species Resource Title
DNA material tFucci(CA)2/pCSII-EF (RDB15446) A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib.
Human and Animal Cells HL60(RCB0041) , U937 , Jurkat Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells.
Human and Animal Cells TFK-1(RCB2537) SRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting BIN1, MCL-1 and BCL2 Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells.
DNA material CS-RfA-EG (RDB04391) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Human and Animal Cells K562(RCB0027) Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance.
Human and Animal Cells Ba/F3(RCB0805) , K562 FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5.
Human and Animal Cells COLO-320(RCB1193) Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer.
Human and Animal Cells RBE(RCB1292) EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma.
Human and Animal Cells Ba/F3 Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.
Human and Animal Cells NUGC-4(RCB1939) , MKN7(RCB0999) , MKN45(RCB1001) ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.
Human and Animal Cells Ba/F3-CL1(RCB4474) Secondary Mutations of the EGFR Gene That Confer Resistance to Mobocertinib in EGFR Exon 20 Insertion.
Human and Animal Cells Li-7(RCB1941) WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.
Human and Animal Cells Ba/F3(RCB0805) The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics.
Human and Animal Cells JMSU1(RCB2227) Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Human and Animal Cells EBC-1(RCB1965) Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer.
Human and Animal Cells Lu-134-A(RCB0466) , Lu-134-B(RCB0467) Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216.
Human and Animal Cells PK-45H(RCB1973) , PK-59(RCB1901) , MIA Paca2(RCB2094) , PANC-1(RCB2095) , PK-1(RCB972) Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor.
Human and Animal Cells EoL-1 cell(RCB0641) p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells.
Human and Animal Cells 9-15C(RCB2323) A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.